Vitamin E in high doses is not the risk of osteoporosis

In this month's science journal Purosuwan, vitamin E administration of high doses of basic research which showed the data that does not cause bone loss, has been reported from the research group of Eisai. (PLoS One 2015 Jul 6; 10 (7):. E0132059.) Oxidative stress, affect the bone metabolism / bone turnover. Antioxidants such as vitamin E, to suppress a decrease in bone density that occurs with age, and is thought to reduce the fracture risk and osteoporosis risk. On the other hand, in 2012, a group of Keio University is, in basic research using rats and mice, Vitamin E in high doses, via a giant osteoclast promote bone resorption, cause osteoporosis, has presented data that. This time, which can result in osteoporosis vitamin E, as has been widely reported in Japan. (As usual, the mass media, in relation to supplements including the vitamin, so pick up significantly only negative data, I think even those who store come.) (It should be noted that the parties of the actual research announcement, In Japan of vitamin E supplements, there is no problem if you are taking to the street of the label, and it says. Only, and or overdose, you can have revealed excess amount such as US-made supplements, it can be a risk in case that, it is a story that. ) Well, In this study, By using a normal rat, α-tocopherol (vitamin E) by bone density, bone mass, bone microstructure, bone resorption, the impact on bone formation, has been validated by quantitative computed tomography (QCT). In particular, Using the normal Wistar female rats, α-tocopherol, 0, 30, 120, or 600 mg / kg diet In doses are administered 8 weeks, As bone mineral quantitative, Quantitative computed tomography evaluation in (QCT) / peripheral bone QCT (pQCT) was held. Also, It has been made also verification using menopausal model rats and sham-operated rats. As a result of the analysis, First, In menopause model rats, bone density of the lumbar spine and femoral distal metaphyseal had decreased. Also, In cancellous bone of the vertebral body and distal femur metaphysis, Deterioration of reduction and bone microstructure of bone mass has also been detected. In addition, In cancellous bone at the same site, it has been also found a decrease in bone mass. On the contrary, The α-tocopherol (vitamin E) administration group, In normal rats, and also in the administration group of high-dose, It decreased bone density of the lumbar spine and femoral distal metaphyseal was not observed, Changes in the reduction and bone microstructure of bone mass in the cancellous bone did not even been detected. Rather, The α-tocopherol administration group, In the cavernous body bone of bone remodeling is active vertebral body bone, Increase of bone mass by promoting bone formation is that has been found. From the above data, Administration of α-tocopherol / vitamin E, are suggested to be useful for the health of the bone. In the future, verification of clinical significance is expected. By the way, The study, in the general media, absolutely, not been reported. New research data that vitamin E is good for your health, such as, without in the mass media is reporting, If it is negative data, even those such as the basic research of Keio University described above, there is a bias that is greater coverage. The results of recent years of evidence building, Proper use of supplements and functional foods, but is clear that to contribute to the realization of healthy longevity society, Double standard of prejudice and publicity for supplements it felt that still remain. In general, As in Japan, in a relatively rich state is the average diet, Such as multi-vitamin and multi-mineral, significant health improvement functionality action by supplementation of slow functional ingredient I think difficult to realize. On the other hand, in the National Health and Nutrition Examination Survey of the ministry, In the diet of the average Japanese, Insufficient intake of calcium, Insufficient intake of magnesium, Insufficient intake of zinc has been reported. Especially, In young women, it is considered the risk of potential shortage of micronutrients by excessive diet of own way. Therefore, dozens mineral shortage intake has been shown to Over the years past (calcium, magnesium, zinc) for, rather than as "Let's take a ○○ of rich ingredients of ○○" Safety, efficacy, and we believe that is better to be good use of the multi-mineral supplements with excellent balance of (about several hundred yen per month) economy. On the other hand, in clinical studies in developed countries, by the administration of vitamin and mineral supplements, example for disorderly conduct health promotion and disease prevention effect is limited and, many have become negative data a shortage detection. (It should be noted, The decrease of the total cancer mortality by antioxidant vitamin supplementation in France of male smokers, The decrease of the total cancer mortality by multi-vitamin supplementation in the US male physicians, Effects such as has been reported. ) In general, supplements of multi-vitamins and multi-minerals, will be used for the purpose of supplementing the missing in the diet tend to essential nutrients. Therefore, it is not a compelling subject areas where there is a problem in nutritional status, A multi-vitamin supplements, cancer prevention and mortality reduction, it does not result in. (In the case of the Japanese, the problem of the lack of potential nutrients in the modern diet but is assumed, Until the data that the mortality rate decreased in the administration of multi-vitamin I think that it can not be detected. ) (It should be noted, As a multi-vitamin mechanism of anti-cancer effects and mortality reduction due to mineral supplements, Vitamin C and vitamin E, ingredients with antioxidant such as selenium, Through the inhibition of oxidative damage, it shows the anti-cancer effects and lifestyle-related disease prevention effect, It becomes. ) Respect to multi-vitamin supplements and cancer, In study of 14,641 people or more 50-year-old US male physicians, The cancer risk reduction effect by the multi-vitamin It has been reported data that. (It is this time of the review.) Also, Of multi-vitamins and minerals and mortality relationship: meta-analysis There are also reports that. In addition, health promotion and disease prevention, is a suitable diet and exercise habits are basic, supplements and health food does not replace them. The recommended paper multi-vitamin intake by medical journals, and has been known following two Tsugayoku. (1) editorial in NEJM magazine (1998) "Eat Right and Take a Multivitamin" "It takes a proper diet, multivitamin also Let's use" (Neural tube defects prevention, significance of atherosclerotic disease prevention) (Oakely GP. NEJM. 1998 Editorial) A review of (2) JAMA magazine (2002) "Vitamins for chronic disease prevention in adults." "Adults, every day, you should consume a multi-vitamin supplements." (Although in developed countries deficiency is rare, there is a risk of that is below the optimum concentration.) (Fletcher.et al. JAMA. 2002) In DHC, high-quality multi-vitamins at a reasonable price, multi-mineral, offers a calcium-magnesium. In addition, other multi-carotene including various carotenoids, lycopene, lutein, etc. also commercialized. For middle-aged or more of disease prevention and health promotion is, The following supplements, it all can be recommended intake as basic supplements. Cost of all of the intake in one month, from about 2,000 yen, because it is, In addition to safety and efficacy, also it has excellent economic efficiency (cost-effectiveness). Multi-vitamin, (Multi-vitamin economical 90 days \ 886 (tax included \ 956)) ⇒1-month yen about 300. Multi-mineral, (Multi-mineral economical 90 days [Functional food nutrition (iron, zinc, magnesium)] \ 1,239 (including tax \ 1,338)) ⇒1 months worth about 450 yen. Vitamin C hard capsules (1,000mg) (Vitamin C (hard capsules) economical 90 days [nutrient function food (vitamin C · vitamin B2)] \ 629 (tax included \ 679)) ⇒1 months worth about 210 yen. Vitamin D3 (Vitamin D3 30 days \ 286 (tax included \ 308)) ⇒1 months worth about 300 yen. Coenzyme Q10, (Coenzyme Q10 clathrate economical 90 days usually price \ 2,143 (tax)) ⇒1 months worth about 700 yen. ↑ above, is about one month worth about 2,000 yen in total. It is a basic component that can be recommended for more than all middle-aged and elderly. ↓ the following ingredients, in case you want to add in addition to the above, it is a supplement that is priority. EPA, (EPA 30 days \ 950 (tax included \ 1,026)) DHA, (DHA 30 days \ 1,191 (including tax \ 1,286)) Lactic acid bacteria (Reach bifidus 30 days usually price \ 1,429 (tax))