Improving action of neuromotor ability in HIV-infected persons with vitamin D supplements

Professional journal of the month of musculoskeletal research, in HIV-infected persons, clinical studies that examined the function of the nervous motor function with vitamin D supplementation, has been reported from the United States of the group. (. J Musculoskelet Neuronal Interact 2015 Jun; 15 (2): 145-53.) In this study, Work to the musculoskeletal system by vitamin D3 supplements has been verified. In particular, As randomized controlled trials, From 9 years old to target the HIV-infected persons 56 persons of 25-year-old, Vitamin D3 supplements of 7,000 IU per day Alternatively One of the placebo 12 months have been administered. Evaluation of motor nerve capacity (Neuromuscular motor skills) (Bruininks-Oseretsky Test of Motor Proficiency) and strength (jumping ability and jump height, such as the lower limbs of the extension) has been measured. As a result of the analysis, First, Blood vitamin D value [25 (OH) D] is, As compared to the placebo group, the vitamin D3 supplementation, I grew significantly (Β = 12.1 ng / mL; P <0.001) Then, By ITT analysis, Motor nerve function, neuromuscular motor nerve capacity, compared to the placebo group, Significant improvement in the vitamin D3 supplementation group is that was observed. (Β = 1.14; P = 0.041) In addition, Jumping ability and jump height, for such as muscle strength, significant difference between the two groups was not shown. From the above data, In the young people of HIV infection, Improving effect of motor nerve capacity by the administration of vitamin D3 supplements are suggested. In recent years, Vitamin D, not only health of bones and immunomodulatory effects and anti-cancer activity, has been shown various effects. In general, Health maintenance and disease prevention, vitamin D3 supplements for the purpose of healthy aging, Per day From 25 micrograms (1,000 IU), it is recommended 50 micrograms (2,000 IU) Vitamin D3 supplements, safety, efficacy, since it has excellent economy, a prerequisite to improve the nutritional status in health maintenance and disease prevention, or a number of diseases, recommended to be widely used as a basic supplements You can do it. Many of the lifestyle-related diseases and chronic diseases, in the group of patients with refractory disease, has been shown vitamin D low value, has been attracting attention is the clinical significance of vitamin D supplements. Related Society in the United States, has a recommended below. US Geriatrics Association, recommends 4,000 IU per day In the United States Geriatrics Society (AGS), in order to prevent falls and fractures in the elderly, blood vitamin D value (25OH-D) is 30 ng / mL (75 nmol / L) is in need. And, the recommended amount of vitamin D, it is with 4,000 IU per day. (This is, diet, supplements, is the total amount due to sun exposure. It should be noted that this amount, because in practice it is not possible from diet alone, will be used to supplement. ) US Endocrine Society, recommends 1,500 IU ~ 2,000 IU per day In the guidelines of the US Endocrine Society, by the required both men and women age per day, it is divided into the following three stages. Infants under the age of 1 400 ~ 1,000 IU, And 600 ~ 1,000 IU in 1-year-old to 18-year-old, In the 19 years of age or older 1,500 IU ~ 2,000 IU In the supplement, it is used vitamin D3. In the report from Japan, Flu preventive effect of vitamin D supplements It has been known. In addition, in various lifestyle-related diseases, it is known that blood vitamin D value is low, for health maintenance and disease prevention, it is recommended intake of vitamin D supplements. (By that deficiency of prevention will compensate even from a normal diet, but in the purpose of disease prevention, from 1,000 to 2,000 per day It is necessary to intake of IU, it will be to use the supplement. ) Today, while diseases such as typical example of vitamin D deficiency is less, from the low value of blood vitamin D is widely recognized, the use of vitamin D supplements for the purpose of prevention and anti-aging lifestyle-related diseases is recommended It is. Even among Japanese, potential shortage / deficiency of vitamin D has become noticeable. For example, 90% of Japanese pregnant women vitamin D deficiency, Low blood vitamin D value is higher and colon adenoma risk There is data that. In DHC, it is the product of a vitamin D3 supplement. Although there are individual differences in the effects on vitamin D supplements, Clinically, the administration of vitamin D supplements at a dose of 1,000 IU / day, blood 25-hydroxyvitamin D values ​​increase 10ng / mL, There are also reports that. Since vitamin D multi-vitamin is the setting for the RDA, separately, it will be the use of vitamin D supplements.