The autism spectrum disorder improving action by vitamin D

Specialized journal (electronic version) of the month of neurology, in autism spectrum disorders, clinical research had been reported that examined the effect of state and vitamin D supplementation of vitamin D. (Nutr Neurosci. 2015 Apr 15.) Autism (Autism spectrum disorder, ASD, autism spectrum disorders), the relationship of the social life and difficult observed in such communication in a language and non-language. In previous research, Vitamin D deficiency in autism spectrum disorders have been found. However, the association between severity and vitamin D deficiency in autism is not clear. Therefore, In the present study, and vitamin D deficiency, the severity of the autism spectrum disorders, and the effects of vitamin D supplementation it has been verified. In particular, Targeting 122 people children with autism spectrum disorders (ASD), It is compared to the control group and the vitamin D value, associated with the severity was examined. Also, As an open label study, Vitamin D supplementation to the ASD children have been made. As a result of the analysis, ASD among pediatric patients, 57% is a vitamin D deficiency, 30% has been determined that vitamin D deficiency. Blood vitamin D values, In severe ASD patients, Compared to the ASD patients with mild / moderate, It is that it was more low value. Blood vitamin D levels (25-OHD) is, And childhood autism rating scale (CARS) score, was found significant negative correlation. Among the ASD group, vitamin D low value 106 people who showed a (<30 ng / ml), has participated in the open-label study. Subjects, Vitamin D3 supplements, At 300 IU / kg body weight dose per day, (However, in a dose not exceeding 5,000 IU / day) 3 months, it has been ingested. 83 people have completed the test. As a result of the analysis, 80.72% of the subjects (67/83) is, by vitamin D3 supplementation, Improvement of autism score (CARS) was observed, Behavior and eye contact, is that attention, such as has been improved. finally, In subjects with vitamin D value is equal to or greater than 40 ng / ml, it has been found favorable. From the above data, In autism spectrum disorders, and that vitamin D deficiency / shortage is found widely, That negative correlation is observed between the severity and blood vitamin D values ​​of the disease, It is suggested that the improvement of the symptoms can be expected by vitamin D3 supplementation. In recent years, Vitamin D, not only health of bones and immunomodulatory effects and anti-cancer activity, has been shown various effects. In general, Health maintenance and disease prevention, vitamin D3 supplements for the purpose of healthy aging, Per day From 25 micrograms (1,000 IU), it is recommended 50 micrograms (2,000 IU) Vitamin D3 supplements, safety, efficacy, since it has excellent economy, a prerequisite to improve the nutritional status in health maintenance and disease prevention, or a number of diseases, recommended to be widely used as a basic supplements You can do it. Many of the lifestyle-related diseases and chronic diseases, in the group of patients with refractory disease, has been shown vitamin D low value, has been attracting attention is the clinical significance of vitamin D supplements. Related Society in the United States, has a recommended below. US Geriatrics Association, recommends 4,000 IU per day In the United States Geriatrics Society (AGS), in order to prevent falls and fractures in the elderly, blood vitamin D value (25OH-D) is 30 ng / mL (75 nmol / L) is in need. And, the recommended amount of vitamin D, it is with 4,000 IU per day. (This is, diet, supplements, is the total amount due to sun exposure. It should be noted that this amount, because in practice it is not possible from diet alone, will be used to supplement. ) US Endocrine Society, recommends 1,500 IU ~ 2,000 IU per day In the guidelines of the US Endocrine Society, by the required both men and women age per day, it is divided into the following three stages. Infants under the age of 1 400 ~ 1,000 IU, And 600 ~ 1,000 IU in 1-year-old to 18-year-old, In the 19 years of age or older 1,500 IU ~ 2,000 IU In the supplement, it is used vitamin D3. In the report from Japan, Flu preventive effect of vitamin D supplements It has been known. In addition, in various lifestyle-related diseases, it is known that blood vitamin D value is low, for health maintenance and disease prevention, it is recommended intake of vitamin D supplements. (By that deficiency of prevention will compensate even from a normal diet, but in the purpose of disease prevention, from 1,000 to 2,000 per day It is necessary to intake of IU, it will be to use the supplement. ) Today, while diseases such as typical example of vitamin D deficiency is less, from the low value of blood vitamin D is widely recognized, the use of vitamin D supplements for the purpose of prevention and anti-aging lifestyle-related diseases is recommended It is. Even among Japanese, potential shortage / deficiency of vitamin D has become noticeable. For example, 90% of Japanese pregnant women vitamin D deficiency, Low blood vitamin D value is higher and colon adenoma risk There is data that. In DHC, it is the product of a vitamin D3 supplement. Although there are individual differences in the effects on vitamin D supplements, Clinically, the administration of vitamin D supplements at a dose of 1,000 IU / day, blood 25-hydroxyvitamin D values ​​increase 10ng / mL, There are also reports that. Since vitamin D multi-vitamin is the setting for the RDA, separately, it will be the use of vitamin D supplements.