The autism spectrum disorder improving action by vitamin D

Specialized journal (electronic version) of the month of neurology, in autism spectrum disorders, clinical research had been reported that examined the effect of state and vitamin D supplementation of vitamin D. (Nutr Neurosci. 2015 Apr 15.) Autism (Autism spectrum disorder, ASD, autism spectrum disorders), the relationship of the social life and difficult observed in such communication in a language and non-language. In previous research, Vitamin D deficiency in autism spectrum disorders have been found. However, the association between severity and vitamin D deficiency in autism is not clear. Therefore, In the present study, and vitamin D deficiency, the severity of the autism spectrum disorders, and the effects of vitamin D supplementation it has been verified. In particular, Targeting 122 people children with autism spectrum disorders (ASD), It is compared to the control group and the vitamin D value, associated with the severity was examined. Also, As an open label study, Vitamin D supplementation to the ASD children have been made. As a result of the analysis, ASD among pediatric patients, 57% is a vitamin D deficiency, 30% has been determined that vitamin D deficiency. Blood vitamin D values, In severe ASD patients, Compared to the ASD patients with mild / moderate, It is that it was more low value. Blood vitamin D levels (25-OHD) is, And childhood autism rating scale (CARS) score, was found significant negative correlation. Among the ASD group, vitamin D low value 106 people who showed a (<30 ng / ml), has participated in the open-label study. Subjects, Vitamin D3 supplements, At 300 IU / kg body weight dose per day, (However, in a dose not exceeding 5,000 IU / day) 3 months, it has been ingested. 83 people have completed the test. As a result of the analysis, 80.72% of the subjects (67/83) is, by vitamin D3 supplementation, Improvement of autism score (CARS) was observed, Behavior and eye contact, is that attention, such as has been improved. finally, In subjects with vitamin D value is equal to or greater than 40 ng / ml, it has been found favorable. From the above data, In autism spectrum disorders, and that vitamin D deficiency / shortage is found widely, That negative correlation is observed between the severity and blood vitamin D values ​​of the disease, It is suggested that the improvement of the symptoms can be expected by vitamin D3 supplementation. In recent years, Vitamin D, not only health of bones and immunomodulatory effects and anti-cancer activity, has been shown various effects. In general, Health maintenance and disease prevention, vitamin D3 supplements for the purpose of healthy aging, Per day From 25 micrograms (1,000 IU), it is recommended 50 micrograms (2,000 IU) Vitamin D3 supplements, safety, efficacy, since it has excellent economy, a prerequisite to improve the nutritional status in health maintenance and disease prevention, or a number of diseases, recommended to be widely used as a basic supplements You can do it. Many of the lifestyle-related diseases and chronic diseases, in the group of patients with refractory disease, has been shown vitamin D low value, has been attracting attention is the clinical significance of vitamin D supplements. Related Society in the United States, has a recommended below. US Geriatrics Association, recommends 4,000 IU per day In the United States Geriatrics Society (AGS), in order to prevent falls and fractures in the elderly, blood vitamin D value (25OH-D) is 30 ng / mL (75 nmol / L) is in need. And, the recommended amount of vitamin D, it is with 4,000 IU per day. (This is, diet, supplements, is the total amount due to sun exposure. It should be noted that this amount, because in practice it is not possible from diet alone, will be used to supplement. ) US Endocrine Society, recommends 1,500 IU ~ 2,000 IU per day In the guidelines of the US Endocrine Society, by the required both men and women age per day, it is divided into the following three stages. Infants under the age of 1 400 ~ 1,000 IU, And 600 ~ 1,000 IU in 1-year-old to 18-year-old, In the 19 years of age or older 1,500 IU ~ 2,000 IU In the supplement, it is used vitamin D3. In the report from Japan, Flu preventive effect of vitamin D supplements It has been known. In addition, in various lifestyle-related diseases, it is known that blood vitamin D value is low, for health maintenance and disease prevention, it is recommended intake of vitamin D supplements. (By that deficiency of prevention will compensate even from a normal diet, but in the purpose of disease prevention, from 1,000 to 2,000 per day It is necessary to intake of IU, it will be to use the supplement. ) Today, while diseases such as typical example of vitamin D deficiency is less, from the low value of blood vitamin D is widely recognized, the use of vitamin D supplements for the purpose of prevention and anti-aging lifestyle-related diseases is recommended It is. Even among Japanese, potential shortage / deficiency of vitamin D has become noticeable. For example, 90% of Japanese pregnant women vitamin D deficiency, Low blood vitamin D value is higher and colon adenoma risk There is data that. In DHC, it is the product of a vitamin D3 supplement. Although there are individual differences in the effects on vitamin D supplements, Clinically, the administration of vitamin D supplements at a dose of 1,000 IU / day, blood 25-hydroxyvitamin D values ​​increase 10ng / mL, There are also reports that. Since vitamin D multi-vitamin is the setting for the RDA, separately, it will be the use of vitamin D supplements.

CRP lowering effects by vitamin E in high doses

Professional journal of the month of nutrition, clinical research that validates the CRP-lowering effect due to vitamin E (anti-inflammatory effect), has been reported from a group of Germany. (Br J Nutr 2015 Apr 21:. 1-10.) In this study, In the general consumer, 5 types of antioxidant nutrients (vitamin E, vitamin C, carotenoids, selenium, zinc) and, Association between blood hs-CRP value, which is a marker of inflammation were examined. In particular, As a cross-sectional study, To target the 2,924 participants, It performs a personal interview, has been examined taking situation of intake and medicines of the past seven days supplements. (It is part of the research that the Cooperative Health Research in the Region of Augsburg (KORA) F4 study (2006-8).) Dose-dependent in quartiles is verified, In addition, And the single administration of each nutrient, also has been validated action for the combined administration. As a result of the analysis, First, Five types of nutrients, in itself, the correlation between hs-CPR was not observed. Then, According to a dose-dependent analysis, In the quartile over 78mg per day hitting the highest group in vitamin E intake group, Compared to vitamin E non-intake group, hs-CRP value is that it was 22% lower. (95% CI 0 • 63, 0 • 97) In addition, In stratified analysis, Correlation of vitamin E and the hs-CRP reduction in high doses, Vitamin E in the group are taking with other antioxidants only, it is that has been found. From the above data, Anti-inflammatory effects by combined administration of vitamin E and other antioxidants is suggested. In the future, such as the context of disease prevention, it is an area where verification of clinical significance is expected. In DHC, high-quality multi-vitamins at a reasonable price, multi-mineral, offers a calcium-magnesium. In addition, other multi-carotene including various carotenoids, lycopene, lutein, etc. also commercialized. For middle-aged or more of disease prevention and health promotion is, The following supplements, it all can be recommended intake as basic supplements. Cost of all of the intake in one month, from about 2,000 yen, because it is, In addition to safety and efficacy, also it has excellent economic efficiency (cost-effectiveness). Multi-vitamin, (Multi-vitamin economical 90 days \ 886 (tax included \ 956)) ⇒1-month yen about 300. Multi-mineral, (Multi-mineral economical 90 days [Functional food nutrition (iron, zinc, magnesium)] \ 1,239 (including tax \ 1,338)) ⇒1 months worth about 450 yen. Vitamin C hard capsules (1,000mg) (Vitamin C (hard capsules) economical 90 days [nutrient function food (vitamin C · vitamin B2)] \ 629 (tax included \ 679)) ⇒1 months worth about 210 yen. Vitamin D3 (Vitamin D3 30 days \ 286 (tax included \ 308)) ⇒1 months worth about 300 yen. Coenzyme Q10, (Coenzyme Q10 clathrate economical 90 days usually price \ 2,143 (tax)) ⇒1 months worth about 700 yen. ↑ above, is about one month worth about 2,000 yen in total. It is a basic component that can be recommended for more than all middle-aged and elderly. ↓ the following ingredients, in case you want to add in addition to the above, it is a supplement that is priority. EPA, (EPA 30 days \ 950 (tax included \ 1,026)) DHA, (DHA 30 days \ 1,191 (including tax \ 1,286)) Lactic acid bacteria (Reach bifidus 30 days usually price \ 1,429 (tax))

Improving action of neuromotor ability in HIV-infected persons with vitamin D supplements

Professional journal of the month of musculoskeletal research, in HIV-infected persons, clinical studies that examined the function of the nervous motor function with vitamin D supplementation, has been reported from the United States of the group. (. J Musculoskelet Neuronal Interact 2015 Jun; 15 (2): 145-53.) In this study, Work to the musculoskeletal system by vitamin D3 supplements has been verified. In particular, As randomized controlled trials, From 9 years old to target the HIV-infected persons 56 persons of 25-year-old, Vitamin D3 supplements of 7,000 IU per day Alternatively One of the placebo 12 months have been administered. Evaluation of motor nerve capacity (Neuromuscular motor skills) (Bruininks-Oseretsky Test of Motor Proficiency) and strength (jumping ability and jump height, such as the lower limbs of the extension) has been measured. As a result of the analysis, First, Blood vitamin D value [25 (OH) D] is, As compared to the placebo group, the vitamin D3 supplementation, I grew significantly (Β = 12.1 ng / mL; P <0.001) Then, By ITT analysis, Motor nerve function, neuromuscular motor nerve capacity, compared to the placebo group, Significant improvement in the vitamin D3 supplementation group is that was observed. (Β = 1.14; P = 0.041) In addition, Jumping ability and jump height, for such as muscle strength, significant difference between the two groups was not shown. From the above data, In the young people of HIV infection, Improving effect of motor nerve capacity by the administration of vitamin D3 supplements are suggested. In recent years, Vitamin D, not only health of bones and immunomodulatory effects and anti-cancer activity, has been shown various effects. In general, Health maintenance and disease prevention, vitamin D3 supplements for the purpose of healthy aging, Per day From 25 micrograms (1,000 IU), it is recommended 50 micrograms (2,000 IU) Vitamin D3 supplements, safety, efficacy, since it has excellent economy, a prerequisite to improve the nutritional status in health maintenance and disease prevention, or a number of diseases, recommended to be widely used as a basic supplements You can do it. Many of the lifestyle-related diseases and chronic diseases, in the group of patients with refractory disease, has been shown vitamin D low value, has been attracting attention is the clinical significance of vitamin D supplements. Related Society in the United States, has a recommended below. US Geriatrics Association, recommends 4,000 IU per day In the United States Geriatrics Society (AGS), in order to prevent falls and fractures in the elderly, blood vitamin D value (25OH-D) is 30 ng / mL (75 nmol / L) is in need. And, the recommended amount of vitamin D, it is with 4,000 IU per day. (This is, diet, supplements, is the total amount due to sun exposure. It should be noted that this amount, because in practice it is not possible from diet alone, will be used to supplement. ) US Endocrine Society, recommends 1,500 IU ~ 2,000 IU per day In the guidelines of the US Endocrine Society, by the required both men and women age per day, it is divided into the following three stages. Infants under the age of 1 400 ~ 1,000 IU, And 600 ~ 1,000 IU in 1-year-old to 18-year-old, In the 19 years of age or older 1,500 IU ~ 2,000 IU In the supplement, it is used vitamin D3. In the report from Japan, Flu preventive effect of vitamin D supplements It has been known. In addition, in various lifestyle-related diseases, it is known that blood vitamin D value is low, for health maintenance and disease prevention, it is recommended intake of vitamin D supplements. (By that deficiency of prevention will compensate even from a normal diet, but in the purpose of disease prevention, from 1,000 to 2,000 per day It is necessary to intake of IU, it will be to use the supplement. ) Today, while diseases such as typical example of vitamin D deficiency is less, from the low value of blood vitamin D is widely recognized, the use of vitamin D supplements for the purpose of prevention and anti-aging lifestyle-related diseases is recommended It is. Even among Japanese, potential shortage / deficiency of vitamin D has become noticeable. For example, 90% of Japanese pregnant women vitamin D deficiency, Low blood vitamin D value is higher and colon adenoma risk There is data that. In DHC, it is the product of a vitamin D3 supplement. Although there are individual differences in the effects on vitamin D supplements, Clinically, the administration of vitamin D supplements at a dose of 1,000 IU / day, blood 25-hydroxyvitamin D values ​​increase 10ng / mL, There are also reports that. Since vitamin D multi-vitamin is the setting for the RDA, separately, it will be the use of vitamin D supplements.

Vitamin E in high doses is not the risk of osteoporosis

In this month's science journal Purosuwan, vitamin E administration of high doses of basic research which showed the data that does not cause bone loss, has been reported from the research group of Eisai. (PLoS One 2015 Jul 6; 10 (7):. E0132059.) Oxidative stress, affect the bone metabolism / bone turnover. Antioxidants such as vitamin E, to suppress a decrease in bone density that occurs with age, and is thought to reduce the fracture risk and osteoporosis risk. On the other hand, in 2012, a group of Keio University is, in basic research using rats and mice, Vitamin E in high doses, via a giant osteoclast promote bone resorption, cause osteoporosis, has presented data that. This time, which can result in osteoporosis vitamin E, as has been widely reported in Japan. (As usual, the mass media, in relation to supplements including the vitamin, so pick up significantly only negative data, I think even those who store come.) (It should be noted that the parties of the actual research announcement, In Japan of vitamin E supplements, there is no problem if you are taking to the street of the label, and it says. Only, and or overdose, you can have revealed excess amount such as US-made supplements, it can be a risk in case that, it is a story that. ) Well, In this study, By using a normal rat, α-tocopherol (vitamin E) by bone density, bone mass, bone microstructure, bone resorption, the impact on bone formation, has been validated by quantitative computed tomography (QCT). In particular, Using the normal Wistar female rats, α-tocopherol, 0, 30, 120, or 600 mg / kg diet In doses are administered 8 weeks, As bone mineral quantitative, Quantitative computed tomography evaluation in (QCT) / peripheral bone QCT (pQCT) was held. Also, It has been made also verification using menopausal model rats and sham-operated rats. As a result of the analysis, First, In menopause model rats, bone density of the lumbar spine and femoral distal metaphyseal had decreased. Also, In cancellous bone of the vertebral body and distal femur metaphysis, Deterioration of reduction and bone microstructure of bone mass has also been detected. In addition, In cancellous bone at the same site, it has been also found a decrease in bone mass. On the contrary, The α-tocopherol (vitamin E) administration group, In normal rats, and also in the administration group of high-dose, It decreased bone density of the lumbar spine and femoral distal metaphyseal was not observed, Changes in the reduction and bone microstructure of bone mass in the cancellous bone did not even been detected. Rather, The α-tocopherol administration group, In the cavernous body bone of bone remodeling is active vertebral body bone, Increase of bone mass by promoting bone formation is that has been found. From the above data, Administration of α-tocopherol / vitamin E, are suggested to be useful for the health of the bone. In the future, verification of clinical significance is expected. By the way, The study, in the general media, absolutely, not been reported. New research data that vitamin E is good for your health, such as, without in the mass media is reporting, If it is negative data, even those such as the basic research of Keio University described above, there is a bias that is greater coverage. The results of recent years of evidence building, Proper use of supplements and functional foods, but is clear that to contribute to the realization of healthy longevity society, Double standard of prejudice and publicity for supplements it felt that still remain. In general, As in Japan, in a relatively rich state is the average diet, Such as multi-vitamin and multi-mineral, significant health improvement functionality action by supplementation of slow functional ingredient I think difficult to realize. On the other hand, in the National Health and Nutrition Examination Survey of the ministry, In the diet of the average Japanese, Insufficient intake of calcium, Insufficient intake of magnesium, Insufficient intake of zinc has been reported. Especially, In young women, it is considered the risk of potential shortage of micronutrients by excessive diet of own way. Therefore, dozens mineral shortage intake has been shown to Over the years past (calcium, magnesium, zinc) for, rather than as "Let's take a ○○ of rich ingredients of ○○" Safety, efficacy, and we believe that is better to be good use of the multi-mineral supplements with excellent balance of (about several hundred yen per month) economy. On the other hand, in clinical studies in developed countries, by the administration of vitamin and mineral supplements, example for disorderly conduct health promotion and disease prevention effect is limited and, many have become negative data a shortage detection. (It should be noted, The decrease of the total cancer mortality by antioxidant vitamin supplementation in France of male smokers, The decrease of the total cancer mortality by multi-vitamin supplementation in the US male physicians, Effects such as has been reported. ) In general, supplements of multi-vitamins and multi-minerals, will be used for the purpose of supplementing the missing in the diet tend to essential nutrients. Therefore, it is not a compelling subject areas where there is a problem in nutritional status, A multi-vitamin supplements, cancer prevention and mortality reduction, it does not result in. (In the case of the Japanese, the problem of the lack of potential nutrients in the modern diet but is assumed, Until the data that the mortality rate decreased in the administration of multi-vitamin I think that it can not be detected. ) (It should be noted, As a multi-vitamin mechanism of anti-cancer effects and mortality reduction due to mineral supplements, Vitamin C and vitamin E, ingredients with antioxidant such as selenium, Through the inhibition of oxidative damage, it shows the anti-cancer effects and lifestyle-related disease prevention effect, It becomes. ) Respect to multi-vitamin supplements and cancer, In study of 14,641 people or more 50-year-old US male physicians, The cancer risk reduction effect by the multi-vitamin It has been reported data that. (It is this time of the review.) Also, Of multi-vitamins and minerals and mortality relationship: meta-analysis There are also reports that. In addition, health promotion and disease prevention, is a suitable diet and exercise habits are basic, supplements and health food does not replace them. The recommended paper multi-vitamin intake by medical journals, and has been known following two Tsugayoku. (1) editorial in NEJM magazine (1998) "Eat Right and Take a Multivitamin" "It takes a proper diet, multivitamin also Let's use" (Neural tube defects prevention, significance of atherosclerotic disease prevention) (Oakely GP. NEJM. 1998 Editorial) A review of (2) JAMA magazine (2002) "Vitamins for chronic disease prevention in adults." "Adults, every day, you should consume a multi-vitamin supplements." (Although in developed countries deficiency is rare, there is a risk of that is below the optimum concentration.) (Fletcher.et al. JAMA. 2002) In DHC, high-quality multi-vitamins at a reasonable price, multi-mineral, offers a calcium-magnesium. In addition, other multi-carotene including various carotenoids, lycopene, lutein, etc. also commercialized. For middle-aged or more of disease prevention and health promotion is, The following supplements, it all can be recommended intake as basic supplements. Cost of all of the intake in one month, from about 2,000 yen, because it is, In addition to safety and efficacy, also it has excellent economic efficiency (cost-effectiveness). Multi-vitamin, (Multi-vitamin economical 90 days \ 886 (tax included \ 956)) ⇒1-month yen about 300. Multi-mineral, (Multi-mineral economical 90 days [Functional food nutrition (iron, zinc, magnesium)] \ 1,239 (including tax \ 1,338)) ⇒1 months worth about 450 yen. Vitamin C hard capsules (1,000mg) (Vitamin C (hard capsules) economical 90 days [nutrient function food (vitamin C · vitamin B2)] \ 629 (tax included \ 679)) ⇒1 months worth about 210 yen. Vitamin D3 (Vitamin D3 30 days \ 286 (tax included \ 308)) ⇒1 months worth about 300 yen. Coenzyme Q10, (Coenzyme Q10 clathrate economical 90 days usually price \ 2,143 (tax)) ⇒1 months worth about 700 yen. ↑ above, is about one month worth about 2,000 yen in total. It is a basic component that can be recommended for more than all middle-aged and elderly. ↓ the following ingredients, in case you want to add in addition to the above, it is a supplement that is priority. EPA, (EPA 30 days \ 950 (tax included \ 1,026)) DHA, (DHA 30 days \ 1,191 (including tax \ 1,286)) Lactic acid bacteria (Reach bifidus 30 days usually price \ 1,429 (tax))

Low intake and many head and neck cancer risk of vitamin C

In this month of professional journal of clinical nutrition (electronic version), cohort studies that examined the relationship between the head and neck cancer risk intake of vitamin C is large, has been reported from the Dutch group (Maastricht University). (Am J Clin Nutr. 2015 Jul 8.) Head and neck cancer, is a type of cancer with high morbidity in seventh in the world. In this study, the intake of vitamin C, E and carotenoids, The relationship between the head and neck cancer, has been verified by the large-scale prospective study. In particular, To target 120,852 people registrant of the Netherlands cohort study, As case-control studies, From the start of 1986, after the average 20.3 years of follow-up, 3898 people cohort registrant, 415 people with head and neck cancer cases, [Breakdown: 131 people; oral cancer, 88 people; oropharyngeal cancer / hypopharynx cancer, 193 people; laryngeal cancer] There is now the subject of analysis. Intake of vitamins and carotenoids have been evaluated in quartiles. As a result of the analysis, Intake and vitamin C, Between the head and neck cancer, it was found very significant negative correlation. For all types of head and neck cancer, In quartile of intake of vitamin C, Best group, compared to the lowest group, Significant risk reduction of 61% (0.39; 95% CI: 0.23, 0.66; P-trend <0.001) It was. Also, In oral cancer, Significant risk reduction of 65%, (0.35; 95% CI: 0.16, 0.77; P-trend <0.05) In the oropharyngeal cancer / hypopharynx cancer, Significant risk reduction of 71% (0.29; 95% CI: 0.12, 0.67; P-trend <0.01) It was a correlation that. It should be noted, it does not have significant correlation was observed between the intake of vitamin E and carotenoids. on the other hand, Vitamin E, In the non-ingestion of alcohol's (non-drinking group), Significant correlation with the decrease in head and neck cancer risk has been shown. From the above data, Head and neck cancer risk reduction effect of the intake of vitamin C is suggested. DHC has commercialized the vitamin C supplements. Vitamin C hard capsules (1,000mg) (Vitamin C (hard capsules) economical 90 days [nutrient function food (vitamin C · vitamin B2)] \ 629 (tax included \ 679)) ⇒1 months worth about 210 yen. In DHC, high-quality multi-vitamins at a reasonable price, multi-mineral, offers a calcium-magnesium. In addition, other multi-carotene including various carotenoids, lycopene, lutein, etc. also commercialized. For middle-aged or more of disease prevention and health promotion is, The following supplements, it all can be recommended intake as basic supplements. Cost of all of the intake in one month, from about 2,000 yen, because it is, In addition to safety and efficacy, also it has excellent economic efficiency (cost-effectiveness). Multi-vitamin, (Multi-vitamin economical 90 days \ 886 (tax included \ 956)) ⇒1-month yen about 300. Multi-mineral, (Multi-mineral economical 90 days [Functional food nutrition (iron, zinc, magnesium)] \ 1,239 (including tax \ 1,338)) ⇒1 months worth about 450 yen. Vitamin C hard capsules (1,000mg) (Vitamin C (hard capsules) economical 90 days [nutrient function food (vitamin C · vitamin B2)] \ 629 (tax included \ 679)) ⇒1 months worth about 210 yen. Vitamin D3 (Vitamin D3 30 days \ 286 (tax included \ 308)) ⇒1 months worth about 300 yen. Coenzyme Q10, (Coenzyme Q10 clathrate economical 90 days usually price \ 2,143 (tax)) ⇒1 months worth about 700 yen. ↑ above, is about one month worth about 2,000 yen in total. It is a basic component that can be recommended for more than all middle-aged and elderly. ↓ the following ingredients, in case you want to add in addition to the above, it is a supplement that is priority. EPA, (EPA 30 days \ 950 (tax included \ 1,026)) DHA, (DHA 30 days \ 1,191 (including tax \ 1,286)) Lactic acid bacteria (Reach bifidus 30 days usually price \ 1,429 (tax))